Control Subjects From the Australia Case-Control Study by Protease Inhibitor Type

Among control subjects, a higher FVC percent predicted was found in PI MZ than in PI MM (101.5% vs 98.0%; P = .044). The percentage of emphysema using a threshold of -950 HU tended to be higher in PI MZ case subjects than in PI MM case subjects (14.5% vs 10.9%; P = .084).

Of the 984 probands and 1,723 relatives included in the ICGN study, 43 (4.4%) and 72 (4.2%) were PI MZ, respectively. Quantitative emphysema data were available for 352 probands and 492 relatives, and data on airway wall thickness were available for 299 probands and 415 relatives Health and Care Pharmacy Canada. Table 2 shows the characteristics of probands and relatives by PI type. PI MZ probands tended to have a lower FEV/VC ratio compared with PI MM probands (0.33 vs 0.37; P = .059) (Table 2). Among relatives, the observed differences between PI MM and PI MZ subjects were small (not tested statistically in univariate analysis because of relatedness within the groups).

We examined the associations between PI type and COPD-related phenotypes in multivariate models, adjusting for relevant covariates (Table 3) .

Table 1—Characteristics of Case and Control Subjects From the Norway Case-Control Study by Protease Inhibitor Type

Case Subjects (n = 834) Control Subjects (n = 835)
Characteristic Canadian Viagra online 1MM MZ 1P Value 1MM MZ 1P Value
Sample, No. (%) 790 (94.7) 44 (5.3) 801 (95.9) 34 (4.1)
Male, % 60.3 65.9 nsa 49.7 41.2 ns
Age, y 65.4 ± 10.2 64.5 ± 9.5 ns 55.5 ± 9.6 57.8 ± 10.3 ns
Pack-y smoking 31.8 ± 18.1 27.1 ± 15.7 .089 18.7 ± 13.3 24.1 ± 10.2 .022
Post-BD spirometry FEV! % predicted 51.3 ± 17.3 48.7 ± 18.0 ns 95.1 ± 9.1 97.3 ± 8.7 ns
FVC % predicted 78.5 ± 16.4 79.6 ± 17.4 ns 98.0 ± 9.8 101.5 ± 10.1 .044
FEV/FVC ratio 0.52 ± 0.13 0.49 ± 0.13 .097 0.79 ± 0.04 0.78 ± 0.03 ns
CT scan, emphysema, No. 376 32 407 15
%LAA950 10.9 ± 11.2 14.5 ± 13.9 .084 1.2 ± 2.3 0.8 ± 0.9 ns
CT scan, airways, No. 357 30 378 15
SRWA-Pi10, cm 0.49 ± 0.03 0.50 ± 0.04 ns 0.48 ± 0.03 0.49 ± 0.04 ns

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